Mar 26, 2011 necrotizing sialometaplasia ns is a benign, self limiting inflammatory reaction of salivary gland tissue which may mimic squamous cell carcinoma or mucoepidermoid carcinoma both clinically and histologically and can lead to unnecessary surgical approach. Necrotizing sialometaplasia is a benign inflammatory condition of the salivary gland remnants or elements, which is usually selflimiting. It is thought to be the result of an ischemic event of the vasculature supplying the salivary gland lobules. Case report ct findings of necrotizing sialometaplasia a suomalainen,1,jto.
The lesion begins acutely with swelling and pain or. Here we report a case of necrotizing sialometaplasia in a female on left side of hard palate mimicking carcinoma. Based on histopathological and immunohistochemical findings, we discuss how to distinguish the condition from neoplastic lesions such as squamous cell carcinoma or mucoepidermoid carcinoma. The surgical margins of the specimen and cervical lymph nodes were free of tumor. Necrotizing sialometaplasia necrotizing sialometaplasia is.
Necrotizing sialometaplasia nsm is an uncommon inflammatory condition that affects salivary glands. The ulcerated lesion on the hard palate was treated conservatively and resolved spontaneously in about three months. Necrotizing sialometaplasia was first described in 1973 by abrams, melrose and howell1. Necrotizing sialometaplasia ns is a benign, selflimiting inflammatory reaction of salivary gland tissue which may mimic squamous cell carcinoma or mucoepidermoid carcinoma, both clinically and histologically, that creates diagnostic dilemma leading to unwarranted aggressive surgery. Shaveta garg pg student, department of oral medicine and radiology, guru nanak dev dental college and research institute. A case of sialometaplasia of the soft palate is reported in a 2yearold girl 3 months after she had an adenoidectomy. Necrotizing sialometaplasia nsm is a benign, reactive metaplastic. Necrotizing sialometaplasia is a rare inflammatory necrotizing reactive process that can involve minor and major salivary. For the negative control, phosphate buffered saline was applied in place of the primary antibody. Case report ct findings of necrotizing sialometaplasia.
Review of the literature on necrotizing sialometaplasia. Necrotizing sialometaplasia free download as powerpoint presentation. Download fulltext pdf download fulltext pdf necrotizing sialometaplasia of palate. It is considered by some authors to be a distinct entity and by others to be part of the spectrum of necrotizing sialometaplasia ns. Necrotizing sialometaplasia ns which mimics malignancy both clinically and histopathologically is an uncommon benign, selflimiting inflammatory disease of the mucussecreting minor salivary glands. Necrotizing sialometaplasia in a patient with an eating disorder palatal ulcer accompanied by dental erosion due to bingepurging srm j res dent sci 20.
It appears as an aggressive looking lesion in an adult possibly resembling squamous cell carcinoma and mucoepidermoid carcinoma. Sialometaplasia definition of sialometaplasia by medical. Health, general otorhinolaryngologic diseases care and treatment case studies diagnosis palate diseases. Till date, the diagnosis of ns remains a challenge. Pathology clinic necrotizing sialometaplasia lester dr thompson. Necrotising sialometaplasia a deceptive ulcer of the palate. A 21yearold woman visited a family dentist complaining of swelling and pain in the right hard palate. Necrotizing sialometaplasia uncommon locally destructive inflammatory condition of the salivary glands. The lesion occurs due to vascular ischemia caused by trauma. Necrotizing sialometaplasia, is a benign inflammatory lesion primarily involving the minor salivary glands of the hard palate. Necrotizing sialometaplasia ns is a benign, ulcerative lesion, usually located towards the back of the hard palate. Gland tissue ischaemia has been proposed as the aetiology. The lesion is believed to be the result of vascular ischemia that may be initiated by trauma. The lesions are characterized histologically by an extensive necrosis of the salivary gland tissue together with squamous metaplasia of the ducts.
In 1973, abrams et al first reported this condition. She had been aware of numbness in the right hard plate before this visit. Subacute necrotizing sialadenitis sans is a selflimiting inflammatory lesion of the minor salivary glands of unknown cause. This pathological lesion was first reported in 1973 by abrams et al. Necrotizing sialometaplasia is a benign, selflimited, reactive inflammatory process that involves salivary glands.
Necrotizing sialometaplasia ns is a benign disease showing inflammatory response which occurs in minor salivary glands mimicking a malignant lesion both clinically as well as histopathologically. Jun 23, 2014 necrotizing sialometaplasia ns is a benign, selflimiting inflammatory reaction of salivary gland tissue which may mimic squamous cell carcinoma or mucoepidermoid carcinoma, both clinically and histologically, that creates diagnostic dilemma leading to unwarranted aggressive surgery. Necrotizing sialometaplasia occurred in a 55yearold woman. A case of necrotizing sialometaplasia clinically mimicking a. Necrotizing sialometaplasia international journal of. A case report article pdf available august 2012 with 822 reads. Necrotizing sialometaplasia is a reactive lesion of salivary gland origin.
Necrotizing sialometaplasia is a rare inflammatory necrotizing reactive process that can involve minor and major salivary glands. Physicians should be aware of its clinical and histological traits in order to avoid unnecessary disfiguring surgery. Necrotizing sialometaplasia is a rare lesion that mimics malignant neoplasm, which is characterized by salivary gland metaplasia, necrosis, and inflammation. Necrotizing sialometaplasia is a benign selflimiting lesion of both major and minor salivary glands although more commonly the latter. A case of necrotizing sialometaplasia ns is presented in a female patient, who initially presented as a suspected head and neck malignancy. Often painless, the condition is selflimiting and should heal in 610 weeks. Necrotizing sialometaplasia of hard palate a case report.
Sialometaplasia definition at, a free online dictionary with pronunciation, synonyms and translation. Lisa franklin is an oral pathologist who presented a forensics lecture to the residency. Necrotizing sialometaplasia radiology reference article. Necrotizing sialometaplasia of the parotid gland in a dog ha. In its clinical and histological appearance, it mimics malignancy. Necrotizing sialometaplasia ns is a benign, selflimiting inflammatory reaction of salivary gland tissue which may mimic squamous cell. Necrotizing sialometaplasia affects the salivary glands. Mostly it occurs in the palate and also salivary glands. Necrotizing sialometaplasia ns is a selflimiting benign condition of unknown origin that affects mainly the minor salivary glands on the hard palate. This selflimiting benign lesion is easily confused with malignant tumors. We report a case of necrotizing sialometaplasia arising as bilateral ulcers in the palate of a 20yearold japanese female patient. A further five cases were reported the following year by dunlap and barker. We report the case of a healthy 26yearold man with a painless swelling in the hard palate near the middle raphe, asymptomatic, well limited, and raised edges.
Necrotizing sialometaplasia a diagnostic conundrum dental. We present a case of necrotizing sialometaplasia that presented as an ugly ulcer at the junction of the soft and hard palates. A punctate ulcer on the posterior lateral portion of the hard palate. Necrotizing sialometaplasia is a relatively uncommon oral disorder. Epidemiology most patients are more than 40 years of age, with. This relatively rare condition holds diagnostic importance because of its ambiguous clinical and histopathological presentation that can be misdiagnosed clinically as neoplasia. Necrotizing sialometaplasia necrotizing sialometaplasias. Necrotizing sialometaplasia is a rare, benign inflammatory disease of the minor mucous salivary glands usually caused by glandular ischemia or trauma, that can mimic malignancy, but has a selflimiting character. Mar 29, 2018 necrotizing sialometaplasia ns is a nonneoplastic inflammatory condition of the salivary glands. It is thought to be caused by ischemic necrosis death of tissue due to lack of blood supply of minor salivary glands in response to trauma.
Necrotizing sialometaplasia wikipedia republished wiki 2. Nsm was first described by abrams et al in 19731 and in 1974 it was again reported by dunlap and barker. The clinical and histopathologic features of necrotizing sialometaplasia often simulate those of malignancies such as squamous cell carcinoma or salivary gland malignancy. We report a case of necrotizing sialometaplasia in middle aged women presenting as a nonulcerated swelling. Necrotizing sialometaplasia definition of necrotizing. Reactive, self resolving condition, mostly affecting the palate heals within 6 10 weeks etiology is thought to be reaction to trauma or smoking in the presence of existing tissue ischemia. Apr 16, 2017 these oral pathology videos are mostly recorded in urdu, which was especially recorded to help me out in my second year so i didnt have to go through the book again and again. The cause is local ischemia producing infarction of salivary acini. Jul 11, 2016 necrotizing sialometaplasia is a rare, benign, selflimiting, necrotizing process involving the minor salivary glands, mainly the mucoserous glands of the hard palate. This is caused due to the less blood supply to the salivary glands. Necrotizing sialometaplasia ns is a benign, self limiting inflammatory reaction of salivary gland tissue which may mimic squamous cell carcinoma or mucoepidermoid carcinoma both clinically and histologically and can lead to unnecessary surgical approach. The histology of the lesion consisted of coagulative necrosis of the salivary gland lobules and prominent squamous.
Necrotizing sialometaplasia of the hard palate in a patient. Necrotizing sialometaplasia is a rare benign and selflimiting disease, which commonly affects the minor salivary glands. Some predisposing factors such as smoking, use of alcohol, denture wearing, recent surgery, traumatic injuries. The diagnosis is difficult and can be dont only through a biopsy section as well as clinical history. It is considered by some authors to be a distinct entity 1,2 and by others to be part of the spectrum of necrotizing sialometaplasia ns. Necrotizing sialometaplasia of the hypopharynx shekhar k. Necrotizing sialometaplasia ns is a nonneoplastic inflammatory condition of the salivary glands. The ensuing inflammation causes squamous metaplasia of ducts and hyperplasia of the surface stratified squamous epithelium. The lesion is often misdiagnosed as malignant based on clinical and histological findings. Pdf necrotizing sialometaplasia ns is a benign, selflimiting inflammatory reaction of salivary gland. Franklin has a great style of presentation, and i felt it was important to show others that oral. Necrotizing sialometaplasia after silastic ring vertical.
Necrotizing sialometaplasia ns is an uncommon benign reactive necrotizing inflammatory process involving minor salivary gland that often mimics malignancy both clinically and histopathologically. It predominantly affects salivary tissue and usually involves the palate, although it has. The clinical and histological similarity between this entity and a malignant lesion implies a risk of unnecessary radical treatment. This report presents a patient with ns who suffered from frequent bouts of vomiting subsequent to silastic ring vertical gastroplasty which resulted in remarkably low ph of the.